Comparison between slow sodium channel inactivation in rat slow- and fast-twitch muscle.
نویسندگان
چکیده
منابع مشابه
Chronic hypobaric hypoxia increases isolated rat fast-twitch and slow-twitch limb muscle force and fatigue.
Chronic hypoxia alters respiratory muscle force and fatigue, effects that could be attributed to hypoxia and/or increased activation due to hyperventilation. We hypothesized that chronic hypoxia is associated with phenotypic change in non-respiratory muscles and therefore we tested the hypothesis that chronic hypobaric hypoxia increases limb muscle force and fatigue. Adult male Wistar rats were...
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A study has been made of the isometric twitches of single motor units in the extensor hallucis brevis (EHB) muscle in man. The twitch contraction times ranged from 35 to 98 msec and the pooled results indicated the presence of at least two types of unit. The recorded twitch tensions also varied considerably (from 2 to 14 g) but were not related to the twitch speeds. The twitch tension developed...
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Recent studies indicate that environment can modify skeletal muscle gene expression and transcriptional factors in offspring genes. Therefore, exercising can lead to changes in the gene expression of the future generations. One of the important metabolic factors is PDK4, which is known as the main factor in Pyruvate Dehydrogenase Complex (PDC). This study examined the effects of maternal exerci...
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Mutations in the voltage-gated sodium channel Nav1.7 are linked to inherited pain syndromes such as erythromelalgia (IEM) and paroxysmal extreme pain disorder (PEPD). PEPD mutations impair Nav1.7 fast inactivation and increase persistent currents. PEPD mutations also increase resurgent currents, which involve the voltage-dependent release of an open channel blocker. In contrast, IEM mutations, ...
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Smaller diaphragmatic motor unit potentials (MUPs) compared to MUPs of limb muscles lead to the hypothesis that diaphragmatic muscle fibers, being the generators of MUPs, might be also smaller. We compared autopsy samples of costal diaphragm and vastus lateralis of healthy men with respect to fibers' size and expression of slow myosin heavy chain isoform (MyHC-1) and fast 2A isoform (MyHC-2A). ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1987
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1987.sp016412